Dataset Information
Artificial Macrocycles by Ugi Reaction and Passerini Ring Closure.
Ontology highlight
ABSTRACT:
SUBMITTER: Abdelraheem EM
PROVIDER: S-EPMC6280654 | biostudies-other | 2016 Oct
REPOSITORIES: biostudies-other
Publications
Artificial Macrocycles by Ugi Reaction and Passerini Ring Closure.
The Journal of organic chemistry 20160915 19
Artificial macrocycles can be convergently synthesized by a sequence of an Ugi multicomponent reaction (MCR) followed by an intramolecular Passerini MCR used to close the macrocycle. Significantly, in this work, the first intramolecular macrocyclization through a Passerini reaction is described. We describe 21 macrocycles of a size of 15-20. The resulting macrocyclic depsipeptides are model compounds for natural products and could find applications in drug discovery. ...[more]