Ontology highlight
ABSTRACT:
SUBMITTER: Judson R
PROVIDER: S-EPMC6280881 | biostudies-other | 2016 Aug
REPOSITORIES: biostudies-other
Judson Richard R Houck Keith K Martin Matt M Richard Ann M AM Knudsen Thomas B TB Shah Imran I Little Stephen S Wambaugh John J Woodrow Setzer R R Kothiya Parth P Phuong Jimmy J Filer Dayne D Smith Doris D Reif David D Rotroff Daniel D Kleinstreuer Nicole N Sipes Nisha N Xia Menghang M Huang Ruili R Crofton Kevin K Thomas Russell S RS
Toxicological sciences : an official journal of the Society of Toxicology 20160520 2
Chemical toxicity can arise from disruption of specific biomolecular functions or through more generalized cell stress and cytotoxicity-mediated processes. Here, responses of 1060 chemicals including pharmaceuticals, natural products, pesticidals, consumer, and industrial chemicals across a battery of 815 in vitro assay endpoints from 7 high-throughput assay technology platforms were analyzed in order to distinguish between these types of activities. Both cell-based and cell-free assays showed a ...[more]