Elovl6 regulates mechanical damage-induced keratinocyte death and skin inflammation.
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ABSTRACT:
SUBMITTER: Nakamura Y
PROVIDER: S-EPMC6281680 | biostudies-other | 2018 Dec
REPOSITORIES: biostudies-other
Publications
Elovl6 regulates mechanical damage-induced keratinocyte death and skin inflammation.
Nakamura Yoshiyuki Y Matsuzaka Takashi T Tahara-Hanaoka Satoko S Shibuya Kazuko K Shimano Hitoshi H Nakahashi-Oda Chigusa C Shibuya Akira A
Cell death & disease 20181205 12
Mechanical damage on the skin not only affects barrier function but also induces various immune responses, which trigger or exacerbate skin inflammation. However, how mechanical damage-induced skin inflammation is regulated remains incompletely understood. Here, we show that keratinocytes express the long-chain fatty-acid elongase Elovl6. Mice deficient in Elovl6 showed higher levels of cis-vaccenic acid (CVA) in the epidermis and severe skin inflammation induced by mechanical damage due to tape ...[more]
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