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Elovl6 regulates mechanical damage-induced keratinocyte death and skin inflammation.


ABSTRACT: Mechanical damage on the skin not only affects barrier function but also induces various immune responses, which trigger or exacerbate skin inflammation. However, how mechanical damage-induced skin inflammation is regulated remains incompletely understood. Here, we show that keratinocytes express the long-chain fatty-acid elongase Elovl6. Mice deficient in Elovl6 showed higher levels of cis-vaccenic acid (CVA) in the epidermis and severe skin inflammation induced by mechanical damage due to tape stripping than did wild-type mice. CVA accelerated tape stripping-triggered keratinocyte death and release of danger-associated molecular patterns (DAMPs) such as high-mobility group box 1 protein (HMGB-1) and IL-1?, which induced production of proinflammatory cytokines and chemokines IL-1? and CXCL-1 by keratinocytes. Our results demonstrate that Elovl6 regulates mechanical damage-triggered keratinocyte death and the subsequent dermatitis.

SUBMITTER: Nakamura Y 

PROVIDER: S-EPMC6281680 | biostudies-other | 2018 Dec

REPOSITORIES: biostudies-other

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Elovl6 regulates mechanical damage-induced keratinocyte death and skin inflammation.

Nakamura Yoshiyuki Y   Matsuzaka Takashi T   Tahara-Hanaoka Satoko S   Shibuya Kazuko K   Shimano Hitoshi H   Nakahashi-Oda Chigusa C   Shibuya Akira A  

Cell death & disease 20181205 12


Mechanical damage on the skin not only affects barrier function but also induces various immune responses, which trigger or exacerbate skin inflammation. However, how mechanical damage-induced skin inflammation is regulated remains incompletely understood. Here, we show that keratinocytes express the long-chain fatty-acid elongase Elovl6. Mice deficient in Elovl6 showed higher levels of cis-vaccenic acid (CVA) in the epidermis and severe skin inflammation induced by mechanical damage due to tape  ...[more]

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