Ontology highlight
ABSTRACT:
SUBMITTER: Benmerzoug S
PROVIDER: S-EPMC6283886 | biostudies-other | 2018 Dec
REPOSITORIES: biostudies-other
Nature communications 20181206 1
Silica particles induce lung inflammation and fibrosis. Here we show that stimulator of interferon genes (STING) is essential for silica-induced lung inflammation. In mice, silica induces lung cell death and self-dsDNA release in the bronchoalveolar space that activates STING pathway. Degradation of extracellular self-dsDNA by DNase I inhibits silica-induced STING activation and the downstream type I IFN response. Patients with silicosis have increased circulating dsDNA and CXCL10 in sputum, and ...[more]