Protein biomarker druggability profiling.
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ABSTRACT:
SUBMITTER: Mani S
PROVIDER: S-EPMC6286812 | biostudies-other | 2017 Feb
REPOSITORIES: biostudies-other
Publications
Protein biomarker druggability profiling.
Mani Subramani S Cannon Daniel D Ohls Robin R Oprea Tudor T Mathias Stephen S Ballard Karri K Ursu Oleg O Bologa Cristian C
Journal of biomedical informatics 20170125
Developing automated and interactive methods for building a model by incorporating mechanistic and potentially causal annotations of ranked biomarkers of a disease or clinical condition followed by a mapping into a contextual framework in disease-linked biochemical pathways can be used for potential drug-target evaluation and for proposing new drug targets. We demonstrate the potential of this approach using ranked protein biomarkers obtained in neonatal sepsis by enrolling 127 infants (39 infan ...[more]
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