Ontology highlight
ABSTRACT:
SUBMITTER: Yoshimura A
PROVIDER: S-EPMC6288862 | biostudies-other | 2018 Dec
REPOSITORIES: biostudies-other
Yoshimura Akihiro A Yamada Tadaaki T Okura Naoko N Takeda Takayuki T Furutani Wataru W Kubota Yutaka Y Shiotsu Shinsuke S Hiranuma Osamu O Nishioka Naoya N Chihara Yusuke Y Tamiya Nobuyo N Kaneko Yoshiko Y Uchino Junji J Takayama Koichi K
BMC cancer 20181211 1
<h4>Background</h4>The EGFR-T790M mutation is clinically detected using re-biopsy in approximately 50% of patients with acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in advanced non-small cell lung cancer (NSCLC) who harbor EGFR mutations. However, little is known about the population of NSCLC patients who develop acquired resistance due to the T790M mutation. In this study, we focused on the emergence of the T790M mutation and analyzed patients r ...[more]