Ontology highlight
ABSTRACT:
SUBMITTER: Yin LM
PROVIDER: S-EPMC6289583 | biostudies-other | 2018
REPOSITORIES: biostudies-other
Yin Lei-Miao LM Duan Ting-Ting TT Ulloa Luis L Yang Yong-Qing YQ
Reviews of physiology, biochemistry and pharmacology 20180101
Ezrin is a critical structural protein that organizes receptor complexes and orchestrates their signal transduction. In this study, we review the ezrin-meditated regulation of critical receptor complexes, including the epidermal growth factor receptor (EGFR), CD44, vascular cell adhesion molecule (VCAM), and the deleted in colorectal cancer (DCC) receptor. We also analyze the ezrin-meditated regulation of critical pathways associated with asthma, such as the RhoA, Rho-associated protein kinase ( ...[more]