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Influence of elderly patients' coronary artery lesion severity on cardiac remodeling and left ventricular function.

ABSTRACT: Objective:To analyze the correlation between coronary artery lesion and cardiac function change among elderly patients with coronary heart disease (CHD). Methods:A total of 171 elderly patients with CHD hospitalized from 2009 to 2016 were selected. Their ultrasonic cardiographic and coronary angiographic data were collected, and the correlation between coronary artery lesion and left ventricular remodeling, systolic and diastolic function was analyzed. Results:Coronary artery lesion among elderly patients with CHD was closely related with left ventricular remodeling and systolic function change, but not significantly correlated with diastolic function change. Conclusion:Coronary artery lesion severity of elderly patients with CHD was an important reason for left ventricular remodeling and cardiac systolic function change. Early intervention of coronary artery disease is of great significance to protect the heart function.

SUBMITTER: Wang C

PROVIDER: S-EPMC6290191 | biostudies-other | 2018 Nov-Dec

REPOSITORIES: biostudies-other

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Influence of elderly patients' coronary artery lesion severity on cardiac remodeling and left ventricular function.

Wang Chao C Tian Xiang X Cai Huixin H Feng Liang L

Pakistan journal of medical sciences 20181101 6

<h4>Objective</h4>To analyze the correlation between coronary artery lesion and cardiac function change among elderly patients with coronary heart disease (CHD).<h4>Methods</h4>A total of 171 elderly patients with CHD hospitalized from 2009 to 2016 were selected. Their ultrasonic cardiographic and coronary angiographic data were collected, and the correlation between coronary artery lesion and left ventricular remodeling, systolic and diastolic function was analyzed.<h4>Results</h4>Coronary arte ...[more]

PMID: 30559821

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Project description:BackgroundCoronary artery disease (CAD) is a metabolically perturbed pathological condition. However, the knowledge of metabolic signatures on outcomes of CAD and their potential causal effects and impacts on left ventricular remodeling remains limited. We aim to assess the contribution of plasma metabolites to the risk of death and major adverse cardiovascular events (MACE) as well as left ventricular remodeling.ResultsIn a prospective study with 1606 Chinese patients with CAD, we have identified and validated several independent metabolic signatures through widely-targeted metabolomics. The predictive model respectively integrating four metabolic signatures (dulcitol, β-pseudouridine, 3,3',5-Triiodo-L-thyronine, and kynurenine) for death (AUC of 83.7% vs. 76.6%, positive IDI of 0.096) and metabolic signatures (kynurenine, lysoPC 20:2, 5-methyluridine, and L-tryptophan) for MACE (AUC of 67.4% vs. 59.8%, IDI of 0.068) yielded better predictive value than trimethylamine N-oxide plus clinical model, which were successfully applied to predict patients with high risks of death (P = 0.0014) and MACE (P = 0.0008) in the multicenter validation cohort. Mendelian randomisation analysis showed that 11 genetically inferred metabolic signatures were significantly associated with risks of death or MACE, such as 4-acetamidobutyric acid, phenylacetyl-L-glutamine, tryptophan metabolites (kynurenine, kynurenic acid), and modified nucleosides (β-pseudouridine, 2-(dimethylamino) guanosine). Mediation analyses show that the association of these metabolites with the outcomes could be partly explained by their roles in promoting left ventricular dysfunction.ConclusionsThis study provided new insights into the relationship between plasma metabolites and clinical outcomes and its intermediate pathological process left ventricular dysfunction in CAD. The predictive model integrating metabolites can help to improve the risk stratification for death and MACE in CAD. The metabolic signatures appear to increase death or MACE risks partly by promoting adverse left ventricular dysfunction, supporting potential therapeutic targets of CAD for further investigation.

Dataset Information

Influence of elderly patients' coronary artery lesion severity on cardiac remodeling and left ventricular function.

Publications

Influence of elderly patients' coronary artery lesion severity on cardiac remodeling and left ventricular function.

Similar Datasets

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