REVIEW ARTICLE: Cellular Abnormalities and Emerging Biomarkers in Alcohol Associated Liver Disease.
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ABSTRACT:
SUBMITTER: Singal AK
PROVIDER: S-EPMC6290320 | biostudies-other | 2018 Jul
REPOSITORIES: biostudies-other
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Cellular Abnormalities and Emerging Biomarkers in Alcohol-Associated Liver Disease.
Singal Ashwani K AK Bailey Shannon M SM
Gene expression 20180725 1
Alcohol-associated liver disease (AALD) is the third most common preventable cause for disease burden and mortality in the US. AALD, including alcoholic hepatitis (AH), contributes to half of admissions from decompensated liver disease and 20% of all liver transplants in the US. Peripheral blood cells contribute to systemic inflammation, oxidative stress, mitochondrial dysfunction, and fibrosis in AALD and AH. Alcohol dysregulates function of lymphocytes, neutrophils, monocytes, and tissue macro ...[more]
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