Ontology highlight
ABSTRACT:
SUBMITTER: Zou W
PROVIDER: S-EPMC6292511 | biostudies-other | 2018 May
REPOSITORIES: biostudies-other
Zou Wei W Dong Xintong X Broederdorf Timothy R TR Shen Ao A Kramer Daniel A DA Shi Rebecca R Liang Xing X Miller David M DM Xiang Yang K YK Yasuda Ryohei R Chen Baoyu B Shen Kang K
Developmental cell 20180501 3
Proper morphogenesis of dendrites plays a fundamental role in the establishment of neural circuits. The molecular mechanism by which dendrites grow highly complex branches is not well understood. Here, using the Caenorhabditis elegans PVD neuron, we demonstrate that high-order dendritic branching requires actin polymerization driven by coordinated interactions between two membrane proteins, DMA-1 and HPO-30, with their cytoplasmic interactors, the RacGEF TIAM-1 and the actin nucleation promotion ...[more]