Ontology highlight
ABSTRACT:
SUBMITTER: Nori S
PROVIDER: S-EPMC6294173 | biostudies-other | 2018 Dec
REPOSITORIES: biostudies-other
Nori Satoshi S Khazaei Mohamad M Ahuja Christopher S CS Yokota Kazuya K Ahlfors Jan-Eric JE Liu Yang Y Wang Jian J Shibata Shinsuke S Chio Jonathon J Hettiaratchi Marian H MH Führmann Tobias T Shoichet Molly S MS Fehlings Michael G MG
Stem cell reports 20181121 6
Treatment of chronic spinal cord injury (SCI) is challenging due to cell loss, cyst formation, and the glial scar. Previously, we reported on the therapeutic potential of a neural progenitor cell (NPC) and chondroitinase ABC (ChABC) combinatorial therapy for chronic SCI. However, the source of NPCs and delivery system required for ChABC remained barriers to clinical application. Here, we investigated directly reprogrammed human NPCs biased toward an oligodendrogenic fate (oNPCs) in combination w ...[more]