Ontology highlight
ABSTRACT:
SUBMITTER: Papalazarou V
PROVIDER: S-EPMC6297082 | biostudies-other | 2018 Dec
REPOSITORIES: biostudies-other
Papalazarou Vassilis V Salmeron-Sanchez Manuel M Machesky Laura M LM
Biophysical reviews 20181108 6
Mechanosensing is increasingly recognised as important for tumour progression. Tumours become stiff and the forces that normally balance in the healthy organism break down and become imbalanced, leading to increases in migration, invasion and metastatic dissemination. Here, we review recent advances in our understanding of how extracellular matrix properties, such as stiffness, viscoelasticity and architecture control cell behaviour. In addition, we discuss how the tumour microenvironment can be ...[more]