Suppression of lymphoma growth by the xenoestrogens bisphenol A and genistein.

ABSTRACT: Well-defined physiological functions of estrogens are mediated via nuclear estrogen receptors ? (ER?) and ? (ER?). With regard to hematological malignancies, expression of ER? has been found in both B and T cell lymphomas. In addition to endogenous estrogens or selective ER? agonists, ER? signaling may be affected by both environmental synthetic estrogen-mimicking compounds and dietary phytoestrogens. In the present study we demonstrate that oral exposure with either the synthetic compound bisphenol A (BPA) or the dietary phytoestrogen genistein reduced the growth of grafted murine T cell (EG7) and human B cell (Granta-519 mantle cell) lymphomas which both express ER?. Suppression of lymphoma growth was due to reduced proliferation (BPA and genistein) and induction of apoptosis (genistein). Inhibition of lymphoma growth was seen at a BPA dose of 50 ?g/kg body weight/day considered to be safe human exposure dose or a genistein dose of 1 mg/kg BW/day orally, which is reached in soy-rich diets. Thus, our study indicates that the environmental xenoestrogens BPA and genistein have anti-proliferative effects on ER?-expressing lymphomas. Our data suggest that phytoestrogens may be considered as a dietary supplement for lymphoma patients and possibly for prevention of lymphoid malignancies.

SUBMITTER: Yakimchuk K 

PROVIDER: S-EPMC6300865 | biostudies-other | 2018 Nov

REPOSITORIES: biostudies-other