Ontology highlight
ABSTRACT:
SUBMITTER: Ganuza M
PROVIDER: S-EPMC6302089 | biostudies-other | 2018 Dec
REPOSITORIES: biostudies-other
Nature communications 20181220 1
The embryonic site of definitive hematopoietic stem cell (dHSC) origination has been debated for decades. Although an intra-embryonic origin is well supported, the yolk sac (YS) contribution to adult hematopoiesis remains controversial. The same developmental origin makes it difficult to identify specific markers that discern between an intraembryonic versus YS-origin using a lineage trace approach. Additionally, the highly migratory nature of blood cells and the inability of pre-circulatory emb ...[more]