Ontology highlight
ABSTRACT:
SUBMITTER: Shah UA
PROVIDER: S-EPMC6304886 | biostudies-other | 2018
REPOSITORIES: biostudies-other
Shah Urvi A UA Viswanathan Sengottuvel S Agarwal Beamon B Shastri Aditi A Mantzaris Ioannis I Janakiram Murali M Kornblum Noah N Braunschweig Ira I Verma Amit A Shi Yang Y Reinus John J Derman Olga O
Case reports in oncological medicine 20181203
SOS is a rare complication of stem cell transplantation and has significant morbidity and mortality. We present three cases of SOS and highlight underlying risk factors for its development, such as impaired clearance of alkylating agents (especially melphalan) in patients with renal failure and prolonged infection. Although, melphalan and cyclophosphamide cause SOS less commonly than alkylating agents such as busulfan, physicians must use caution when administering these drugs to patients with u ...[more]