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Down syndrome associated moyamoya may worsen epilepsy control and can benefit from surgical revascularization.


ABSTRACT: Objectives:To examine outcome of bilateral extracranial to intracranial (EC-IC) bypass surgeries for a Down syndrome patient with hard-to-treat epilepsy and moyamoya. Materials and methods:Superficial temporal arteries were anastamosed using an indirect bypass technique to middle cerebral arteries bilaterally to help limit perfusion deficits and seizure controls. Results:Two superficial temporal to middle cerebral artery indirect bypass surgeries were performed within 3?months. Post-revascularization improvements included seizure control, gait, perfusion, wakefulness, language and quality of life. Conclusion:In patients with Down syndrome and moyamoya, improvements in seizure control and quality of life may occur with EC-IC bypass procedures.

SUBMITTER: Garson SR 

PROVIDER: S-EPMC6305662 | biostudies-other | 2019

REPOSITORIES: biostudies-other

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Down syndrome associated moyamoya may worsen epilepsy control and can benefit from surgical revascularization.

Garson Sarah R SR   Monteith Stephen J SJ   Smith Sheila D SD   Keogh Bart P BP   Gwinn Ryder P RP   Doherty Michael J MJ  

Epilepsy & behavior case reports 20181009


<h4>Objectives</h4>To examine outcome of bilateral extracranial to intracranial (EC-IC) bypass surgeries for a Down syndrome patient with hard-to-treat epilepsy and moyamoya.<h4>Materials and methods</h4>Superficial temporal arteries were anastamosed using an indirect bypass technique to middle cerebral arteries bilaterally to help limit perfusion deficits and seizure controls.<h4>Results</h4>Two superficial temporal to middle cerebral artery indirect bypass surgeries were performed within 3 mon  ...[more]

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