Ontology highlight
ABSTRACT:
SUBMITTER: Kalia V
PROVIDER: S-EPMC6306427 | biostudies-other | 2018
REPOSITORIES: biostudies-other
Kalia Vandana V Sarkar Surojit S
Frontiers in immunology 20181220
Interleukin-2 (IL-2) regulates key aspects of CD8 T cell biology-signaling through distinct pathways IL-2 triggers critical metabolic and transcriptional changes that lead to a spectrum of physiological outcomes such as cell survival, proliferation, and effector differentiation. In addition to driving effector differentiation, IL-2 signals are also critical for formation of long-lived CD8 T cell memory. This review discusses a model of rheostatic control of CD8 T cell effector and memory differe ...[more]