Ontology highlight
ABSTRACT:
SUBMITTER: Negre CFA
PROVIDER: S-EPMC6310864 | biostudies-other | 2018 Dec
REPOSITORIES: biostudies-other
Negre Christian F A CFA Morzan Uriel N UN Hendrickson Heidi P HP Pal Rhitankar R Lisi George P GP Loria J Patrick JP Rivalta Ivan I Ho Junming J Batista Victor S VS
Proceedings of the National Academy of Sciences of the United States of America 20181210 52
Determining the principal energy-transfer pathways responsible for allosteric communication in biomolecules remains challenging, partially due to the intrinsic complexity of the systems and the lack of effective characterization methods. In this work, we introduce the eigenvector centrality metric based on mutual information to elucidate allosteric mechanisms that regulate enzymatic activity. Moreover, we propose a strategy to characterize the range of correlations that underlie the allosteric p ...[more]