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Genetic influence of cytokine polymorphisms on the clinical outcome of Japanese gastrointestinal cancer patients in palliative care.


ABSTRACT: Gastrointestinal cancer is one of the most common causes of mortality globally. The present study examined the influence of cytokine genetic polymorphisms [interleukin (IL)-1B C-31T, IL-1RN VNTR, IL-6 C-634G, IL-8 T-251A, IL-10 T-819C and IL-10 A-1082G] on clinical outcomes in patients with gastrointestinal cancer in palliative care. A total of 59 patients with gastrointestinal cancer who were admitted to Iga City General Hospital were analyzed. Genotyping was conducted using a polymerase chain reaction with confronting two-pair primers. Patients with at least one IL-1RN 2 allele demonstrated a significantly better survival (P=0.0275) while those with IL-6-634 G/G demonstrated a worse survival (P=0.0024). Multivariate analyses using the Cox proportional hazard model revealed that those with at least one IL-1RN 2 allele, IL-6-634 G/G or IL-10-1082 A/G had a significantly elevated adjusted hazard ratio of 9.20 (P=0.014), 41.01 (P=0.001) or 6.49 (P=0.046), respectively, compared with those with each homozygous wild-type polymorphism. In addition, the evaluation of weight loss by genotype revealed the potential influence of IL-10 T-819C genotype (P=0.072). IL-1RN, IL-6 and IL-10 polymorphisms were associated with the survival of patients with gastrointestinal cancer, suggesting the clinical feasibility of genetic testing in patients with gastrointestinal cancer in palliative care.

SUBMITTER: Hishida A 

PROVIDER: S-EPMC6313183 | biostudies-other | 2019 Jan

REPOSITORIES: biostudies-other

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Genetic influence of cytokine polymorphisms on the clinical outcome of Japanese gastrointestinal cancer patients in palliative care.

Hishida Asahi A   Okugawa Yoshinaga Y   Morimoto Yuhki Y   Shirai Yumiko Y   Okamoto Kyoko K   Momokita Sachiko S   Ogawa Aki A   Tanaka Koji K   Nishikawa Ryutaro R   Toiyama Yuji Y   Inoue Yasuhiro Y   Sakurai Hiroyuki H   Urata Hisashi H   Tanaka Motoyoshi M   McMillan Donald C DC   Miki Chikao C  

Oncology letters 20181024 1


Gastrointestinal cancer is one of the most common causes of mortality globally. The present study examined the influence of cytokine genetic polymorphisms [interleukin (<i>IL)-1B</i> C-31T, <i>IL-1RN</i> VNTR, <i>IL-6</i> C-634G, <i>IL-8</i> T-251A, <i>IL-10</i> T-819C and <i>IL-10</i> A-1082G] on clinical outcomes in patients with gastrointestinal cancer in palliative care. A total of 59 patients with gastrointestinal cancer who were admitted to Iga City General Hospital were analyzed. Genotypi  ...[more]

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