Microarray-based technologies for the discovery of selective, RNA-binding molecules.
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ABSTRACT:
SUBMITTER: Abulwerdi FA
PROVIDER: S-EPMC6314024 | biostudies-other | 2016 Jul
REPOSITORIES: biostudies-other
Publications
Microarray-based technologies for the discovery of selective, RNA-binding molecules.
Abulwerdi Fardokht A FA Schneekloth John S JS
Methods (San Diego, Calif.) 20160419
The identification of small molecules that bind specifically to RNA is a challenge. However, the recent explosion in knowledge about the role RNA plays in a number of physiological processes apart from coding for protein sequences makes it a highly interesting target for chemical probes and therapeutics. One technology that has played an important role in the discovery of RNA-binding molecules is microarrays. Microarrays have been broadly employed to screen, profile, and quantify RNA interaction ...[more]
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