Ontology highlight
ABSTRACT:
SUBMITTER: Wang KY
PROVIDER: S-EPMC6321515 | biostudies-other | 2018 Dec
REPOSITORIES: biostudies-other
Wang Kai-Yi KY Zhou Zhi-Wen ZW Zhang Heng-Yuan HY Cao Yu-Cheng YC Xu Jin-Yi JY Ma Cong C Meng Qing-Guo QG Bi Yi Y
Molecules (Basel, Switzerland) 20181214 12
Antibiotic resistance has become a serious global problem that threatens public health. In our previous work, we found that ocotillol-type triterpenoid saponin showed good antibacterial activity. Based on preliminary structure-activity relationship, novel serious C-3 substituted ocotillol-type derivatives <b>7</b>⁻<b>26</b> were designed and synthesized. The in vitro antibacterial activity was tested on five bacterial strains (<i>B. subtilis</i> 168, <i>S. aureus</i> RN4220, <i>E. coli</i> DH5α, ...[more]