Ontology highlight
ABSTRACT:
SUBMITTER: Karmakar R
PROVIDER: S-EPMC6331853 | biostudies-other | 2015 Aug
REPOSITORIES: biostudies-other
Karmakar Rajdip R Ghorai Sourav S Xia Yuanzhi Y Lee Daesung D
Molecules (Basel, Switzerland) 20150831 9
Trapping of arynes with various nucleophiles provides a range of heteroatom-functionalized arene derivatives, but the corresponding reaction with water does not provide phenol derivatives. Silver trifluroacetate (AgO₂CCF₃) can nicely solve this problem. It was found that in typical organic solvent, AgO₂CCF₃ readily reacts with arynes to generate trifluoroacetoxy organosilver arene intermediate, which, upon treating with silica gel, provides phenolic products. This protocol can be extended to the ...[more]