Dataset Information
Unconventional Bifunctional Lewis-Bronsted Acid Activation Mode in Bicyclic Guanidine-Catalyzed Conjugate Addition Reactions.
Ontology highlight
ABSTRACT:
SUBMITTER: Cho B
PROVIDER: S-EPMC6331857 | biostudies-other | 2015 Aug
REPOSITORIES: biostudies-other
Publications
Unconventional Bifunctional Lewis-Brønsted Acid Activation Mode in Bicyclic Guanidine-Catalyzed Conjugate Addition Reactions.
Molecules (Basel, Switzerland) 20150818 8
DFT calculations have demonstrated that the unconventional bifunctional Brønsted-Lewis acid activation mode is generally applicable to a range of nucleophilic conjugate additions catalyzed by bicyclic guanidine catalysts. It competes readily with the conventional bifunctional Brønsted acid mode of activation. The optimal pro-nucleophiles for this unconventional bifunctional activation are acidic substrates with low pKa, while the best electrophiles are flexible 1,4-diamide and 1,4-diester conjug ...[more]