Ontology highlight
ABSTRACT:
SUBMITTER: Luo X
PROVIDER: S-EPMC6335415 | biostudies-other | 2019 Jan
REPOSITORIES: biostudies-other
Luo Xiao X Qian Liujia L Xiao Yansheng Y Tang Yao Y Zhao Yang Y Wang Xia X Gu Luyan L Lei Zuhai Z Bao Jianming J Wu Jiahui J He Tingting T Hu Fupin F Zheng Jing J Li Honglin H Zhu Weiping W Shao Lei L Dong Xiaojing X Chen Daijie D Qian Xuhong X Yang Youjun Y
Nature communications 20190116 1
Antimicrobial resistance is a public health emergency and warrants coordinated global efforts. Challenge is that no alternative molecular platform has been identified for discovery of abundant antimicrobial hit compounds. Xanthene libraries have been screened for bioactive compounds. However, the potentially accessible chemistry space of xanthene dyes is limited by the existing xanthene synthesis. Herein we report a mild one-step synthesis, which permits late-stage introduction of a xanthene moi ...[more]