Ontology highlight
ABSTRACT:
SUBMITTER: Pauthner MG
PROVIDER: S-EPMC6335502 | biostudies-other | 2019 Jan
REPOSITORIES: biostudies-other
Pauthner Matthias G MG Nkolola Joseph P JP Havenar-Daughton Colin C Murrell Ben B Reiss Samantha M SM Bastidas Raiza R Prévost Jérémie J Nedellec Rebecca R von Bredow Benjamin B Abbink Peter P Cottrell Christopher A CA Kulp Daniel W DW Tokatlian Talar T Nogal Bartek B Bianchi Matteo M Li Hui H Lee Jeong Hyun JH Butera Salvatore T ST Evans David T DT Hangartner Lars L Finzi Andrés A Wilson Ian A IA Wyatt Richard T RT Irvine Darrell J DJ Schief William R WR Ward Andrew B AB Sanders Rogier W RW Crotty Shane S Shaw George M GM Barouch Dan H DH Burton Dennis R DR
Immunity 20181211 1
Passive administration of HIV neutralizing antibodies (nAbs) can protect macaques from hard-to-neutralize (tier 2) chimeric simian-human immunodeficiency virus (SHIV) challenge. However, conditions for nAb-mediated protection after vaccination have not been established. Here, we selected groups of 6 rhesus macaques with either high or low serum nAb titers from a total of 78 animals immunized with recombinant native-like (SOSIP) Env trimers. Repeat intrarectal challenge with homologous tier 2 SHI ...[more]