Ontology highlight
ABSTRACT:
SUBMITTER: Vallotto C
PROVIDER: S-EPMC6336088 | biostudies-other | 2018 Dec
REPOSITORIES: biostudies-other
Vallotto Claudio C Shaili Evyenia E Shi Huayun H Butler Jennifer S JS Wedge Christopher J CJ Newton Mark E ME Sadler Peter J PJ
Chemical communications (Cambridge, England) 20181201 98
l-Tryptophan (Trp), melatonin (MLT) and the Trp-peptide pentagastrin quenched the formation of azidyl radicals generated on irradiation of the anticancer complex trans,trans,trans-[Pt(pyridine)2(N3)2(OH)2] with visible light, giving rise to C3-centred indole radicals which were characterized for Trp and MLT using an EPR spin-trap; indole, together with azidyl and hydroxyl radicals, have potential roles in a multitargeting mechanism of action against resistant cancers. ...[more]