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Photoactivatable platinum anticancer complex can generate tryptophan radicals.


ABSTRACT: l-Tryptophan (Trp), melatonin (MLT) and the Trp-peptide pentagastrin quenched the formation of azidyl radicals generated on irradiation of the anticancer complex trans,trans,trans-[Pt(pyridine)2(N3)2(OH)2] with visible light, giving rise to C3-centred indole radicals which were characterized for Trp and MLT using an EPR spin-trap; indole, together with azidyl and hydroxyl radicals, have potential roles in a multitargeting mechanism of action against resistant cancers.

SUBMITTER: Vallotto C 

PROVIDER: S-EPMC6336088 | biostudies-other | 2018 Dec

REPOSITORIES: biostudies-other

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Photoactivatable platinum anticancer complex can generate tryptophan radicals.

Vallotto Claudio C   Shaili Evyenia E   Shi Huayun H   Butler Jennifer S JS   Wedge Christopher J CJ   Newton Mark E ME   Sadler Peter J PJ  

Chemical communications (Cambridge, England) 20181201 98


l-Tryptophan (Trp), melatonin (MLT) and the Trp-peptide pentagastrin quenched the formation of azidyl radicals generated on irradiation of the anticancer complex trans,trans,trans-[Pt(pyridine)2(N3)2(OH)2] with visible light, giving rise to C3-centred indole radicals which were characterized for Trp and MLT using an EPR spin-trap; indole, together with azidyl and hydroxyl radicals, have potential roles in a multitargeting mechanism of action against resistant cancers. ...[more]

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