Ontology highlight
ABSTRACT:
SUBMITTER: Menon M
PROVIDER: S-EPMC6336890 | biostudies-other | 2019 Jan
REPOSITORIES: biostudies-other
Menon Malini M Elliott Richard R Bowers Leandra L Balan Nicolae N Rafiq Rumana R Costa-Cabral Sara S Munkonge Felix F Trinidade Ines I Porter Roderick R Campbell Andrew D AD Johnson Emma R ER Esdar Christina C Buchstaller Hans-Peter HP Leuthner Birgitta B Rohdich Felix F Schneider Richard R Sansom Owen O Wienke Dirk D Ashworth Alan A Lord Christopher J CJ
Scientific reports 20190117 1
Inhibition of the PARP superfamily tankyrase enzymes suppresses Wnt/β-catenin signalling in tumour cells. Here, we describe here a novel, drug-like small molecule inhibitor of tankyrase MSC2504877 that inhibits the growth of APC mutant colorectal tumour cells. Parallel siRNA and drug sensitivity screens showed that the clinical CDK4/6 inhibitor palbociclib, causes enhanced sensitivity to MSC2504877. This tankyrase inhibitor-CDK4/6 inhibitor combinatorial effect is not limited to palbociclib and ...[more]