Ontology highlight
ABSTRACT:
SUBMITTER: Amadio P
PROVIDER: S-EPMC6344484 | biostudies-other | 2019 Jan
REPOSITORIES: biostudies-other
Amadio Patrizia P Porro Benedetta B Sandrini Leonardo L Fiorelli Susanna S Bonomi Alice A Cavalca Viviana V Brambilla Marta M Camera Marina M Veglia Fabrizio F Tremoli Elena E Barbieri Silvia S SS
Scientific reports 20190123 1
Circulating levels of Brain Derived Neurotrophic Factor (BDNF) are lower in coronary heart disease (CHD) than in healthy subjects and are associated with coronary events and mortality. However, the mechanism(s) underling this association is not fully understood. We hypothesize that BDNF may influence fibrin fiber structure and clot stability, favoring clot lysis and thrombus resolution. We showed that recombinant BDNF (rh-BDNF) influenced with clot formation in a concentration-dependent manner i ...[more]