Independent validation of induced overexpression efficiency across 242 experiments shows a success rate of 39.
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ABSTRACT:
SUBMITTER: Munkacsy G
PROVIDER: S-EPMC6344512 | biostudies-other | 2019 Jan
REPOSITORIES: biostudies-other
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Independent validation of induced overexpression efficiency across 242 experiments shows a success rate of 39.
Munkácsy Gyöngyi G Herman Péter P Győrffy Balázs B
Scientific reports 20190123 1
Although numerous studies containing induced gene expression have already been published, independent authentication of their results has not yet been performed. Here, we utilized available transcriptomic data to validate the achieved efficiency in overexpression studies. Microarray data of experiments containing cell lines with induced overexpression in one or more genes were analyzed. All together 342 studies were processed, these include 242 different genes overexpressed in 184 cell lines. Th ...[more]
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