Desferrioxamine:gallium-pluronic micelles increase outer membrane permeability and potentiate antibiotic activity against Pseudomonas aeruginosa.
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ABSTRACT:
SUBMITTER: Purro M
PROVIDER: S-EPMC6345168 | biostudies-other | 2018 Dec
REPOSITORIES: biostudies-other
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Desferrioxamine:gallium-pluronic micelles increase outer membrane permeability and potentiate antibiotic activity against Pseudomonas aeruginosa.
Purro Max M Qiao Jing J Liu Zhi Z Ashcraft Morgan M Xiong May P MP
Chemical communications (Cambridge, England) 20181201 99
The outer membrane of Pseudomonas aeruginosa functions primarily as a permeability barrier and imparts a broad spectrum of intrinsic antibiotic resistance. Herein, we describe the synthesis, characterization, and antimicrobial evaluation of a targeted polymeric micelle that specifically permeabilizes the outer membrane and potentiates antibiotic activity against P. aeruginosa. ...[more]
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