Ontology highlight
ABSTRACT:
SUBMITTER: Shimada R
PROVIDER: S-EPMC6345806 | biostudies-other | 2019 Jan
REPOSITORIES: biostudies-other
Shimada Ryuki R Kiso Makoto M Saga Yumiko Y
Scientific reports 20190124 1
In embryonic male germ cells, the RNA-binding protein NANOS2 recruits its target RNAs to processing bodies (P-bodies), where they are repressed. This process is necessary to promote male-type germ cell differentiation. However, it remains unclear whether all NANOS2 functions depend on P-bodies. To address this question, we established ES cell lines containing a germ cell-specific inducible Cre and reporter together with the floxed Ddx6 allele. We deleted the Ddx6 gene by administering tamoxifen ...[more]