Daclatasvir-based regimens in HCV cirrhosis: experience from the Italian early access program.
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ABSTRACT:
SUBMITTER: Calvaruso V
PROVIDER: S-EPMC6345835 | biostudies-other | 2019 Jan
REPOSITORIES: biostudies-other
Publications
Daclatasvir-based regimens in HCV cirrhosis: experience from the Italian early access program.
Calvaruso Vincenza V Mazzarelli Chiara C Milazzo Laura L Badia Lorenzo L Pasulo Luisa L Guaraldi Giovanni G Lionetti Raffaella R Villa Erica E Borghi Vanni V Carrai Paola P Alberti Alfredo A Biolato Marco M Piai Guido G Persico Marcello M Santantonio Teresa T Felder Martina M Angelico Mario M Montalbano Marzia M Mancusi Rossella Letizia RL Grieco Antonio A Angeli Elena E D'Offizi Gianpiero G Fagiuoli Stefano S Belli Luca L Verucchi Gabriella G Puoti Massimo M Craxì Antonio A
Scientific reports 20190124 1
We reported the efficacy and safety data for daclatasvir (DCV)-based all-oral antiviral therapy in patients treated in the Italian compassionate-use program. 275 patients were included (202 male-73.5%, mean age: 57.4 years, 62 HIV-coinfected, 94 with recurrence of hepatitis C post-OLT). Forty-nine patients (17.8%) had Child-Pugh B, Genotype(G) distribution was: G1a:72 patients (26.2%), G1b:137 (49.8%); G3:40 (14.5%) and G4:26 (9.5%). Patients received DCV with sofosbuvir(SOF) (n = 221, 129 with ...[more]
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