Unknown

Dataset Information

0

Prescriber practices and patient adherence to artemisinin-based combination therapy for the treatment of uncomplicated malaria in Guinea, 2016.


ABSTRACT: BACKGROUND:The World Health Organization recommends the use of artemisinin-based combination therapy (ACT) to treat uncomplicated malaria for the control of malaria across the world. There are several types of ACT used across malaria-endemic countries, yet there is little information about preferences and adherence practices regarding different types of ACT. The objective of this study was to evaluate levels of adherence to two types of ACT, artemether-lumefantrine (AL) and artesunate?+?amodiaquine (ASAQ), for the treatment of uncomplicated malaria among prescribers and patients in Guinea in 2016. METHODS:The study included a review of records of malaria patients and three health-facility, cross-sectional surveys. Patients diagnosed with uncomplicated malaria and prescribed ACT (n?=?1830) were recruited and visited in their home after receiving the medication and administered a questionnaire regarding ACT adherence. Prescribers (n?=?115) and drug dispensers (n?=?43) were recruited at the same public health facilities and administered questionnaires regarding prescribing practices and opinions regarding the national treatment policies and protocols. RESULTS:According to the registry review, 35.8% of all-cause consultations were recorded as malaria. Of these, 26.6% were diagnosed clinically without documentation of laboratory confirmation. The diagnosis of uncomplicated malaria represented 64.1% of malaria cases among children under 5 years and 74.9% of those 5 years of age and older. An ACT was prescribed for 83.5% of cases of uncomplicated malaria. Among participants in the study, ACT adherence was 95.4% (95% CI 94.4, 96.3). Overall, about one in four patients (23.4%; 95% CI 21.5, 25.3) reported experiencing adverse events. While patients prescribed ASAQ were significantly more likely to report experiencing adverse effects than patients on AL (p?

SUBMITTER: Camara A 

PROVIDER: S-EPMC6347834 | biostudies-other | 2019 Jan

REPOSITORIES: biostudies-other

altmetric image

Publications

Prescriber practices and patient adherence to artemisinin-based combination therapy for the treatment of uncomplicated malaria in Guinea, 2016.

Camara Alioune A   Moriarty Leah F LF   Guilavogui Timothée T   Diakité Papa Sambou PS   Zoumanigui Joseph Souba JS   Sidibé Sidikiba S   Bah Ibrahima I   Kaba Ibrahima I   Kourouma Djebory D   Zoumanigui Koho K   Plucinski Mateusz M  

Malaria journal 20190125 1


<h4>Background</h4>The World Health Organization recommends the use of artemisinin-based combination therapy (ACT) to treat uncomplicated malaria for the control of malaria across the world. There are several types of ACT used across malaria-endemic countries, yet there is little information about preferences and adherence practices regarding different types of ACT. The objective of this study was to evaluate levels of adherence to two types of ACT, artemether-lumefantrine (AL) and artesunate +   ...[more]

Similar Datasets

| S-EPMC4406189 | biostudies-other
| S-EPMC4333576 | biostudies-other
| S-EPMC1488893 | biostudies-literature
| S-EPMC3350863 | biostudies-other
| S-EPMC1181876 | biostudies-literature
| S-EPMC3909240 | biostudies-literature
| S-EPMC2834703 | biostudies-literature
| S-EPMC6532741 | biostudies-literature
| S-EPMC3196928 | biostudies-literature