Female XX sex chromosomes increase survival and extend lifespan in aging mice.
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ABSTRACT:
SUBMITTER: Davis EJ
PROVIDER: S-EPMC6351820 | biostudies-other | 2019 Feb
REPOSITORIES: biostudies-other
Publications
Female XX sex chromosomes increase survival and extend lifespan in aging mice.
Davis Emily J EJ Lobach Iryna I Dubal Dena B DB
Aging cell 20181217 1
Female longevity is observed in humans and much of the animal kingdom, but its causes remain elusive. Using a genetic manipulation that generates XX and XY mice, each with either ovaries or testes, we show that the female XX sex chromosome complement increases survival during aging in male and female mice. In combination with ovaries, it also extends lifespan. Understanding causes of sex-based differences in aging could lead to new pathways to counter age-induced decline in both sexes. ...[more]
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