Ontology highlight
ABSTRACT:
SUBMITTER: Branco T
PROVIDER: S-EPMC6354899 | biostudies-other | 2010 Sep
REPOSITORIES: biostudies-other
Branco Tiago T Clark Beverley A BA Häusser Michael M
Science (New York, N.Y.) 20100812 5999
The detection and discrimination of temporal sequences is fundamental to brain function and underlies perception, cognition, and motor output. By applying patterned, two-photon glutamate uncaging, we found that single dendrites of cortical pyramidal neurons exhibit sensitivity to the sequence of synaptic activation. This sensitivity is encoded by both local dendritic calcium signals and somatic depolarization, leading to sequence-selective spike output. The mechanism involves dendritic impedance ...[more]