Ontology highlight
ABSTRACT:
SUBMITTER: Dorri F
PROVIDER: S-EPMC6355807 | biostudies-other | 2019
REPOSITORIES: biostudies-other
Dorri Fatemeh F Jewell Sean S Bouchard-Côté Alexandre A Shah Sohrab P SP
Communications biology 20190131
Somatic mutations are a primary contributor to malignancy in human cells. Accurate detection of mutations is needed to define the clonal composition of tumours whereby clones may have distinct phenotypic properties. Although analysis of mutations over multiple tumour samples from the same patient has the potential to enhance identification of clones, few analytic methods exploit the correlation structure across samples. We posited that incorporating clonal information into joint analysis over mu ...[more]