Safety and efficacy of wiping lid margins with lid hygiene shampoo using the "eye brush", a novel lid hygiene item, in healthy subjects: a pilot study.

ABSTRACT: BACKGROUND:To evaluate the safety and efficacy of using a lid hygiene brush prototype to wipe the lid margins with lid hygiene shampoo in subjects with normal meibomian glands. METHODS:Twelve eyes of 6 subjects were all evaluated just before and after wiping lid margins using 1) tap water alone, 2) Eye Shampoo, 3) Eye Brush, or 4) both products, each during a different week. The results after using both products twice daily for 1?month were also evaluated. Wiping efficacy was determined by post-wiping scores for the remaining fluorescein-stained 0.3% Tarivid ointment fully applied to eyelids and lid margins under microscopic view illuminated by blue light just after performing each of the four lid hygiene methods described above. RESULTS:No significant deterioration in ocular conditions occurred. Eyestrain, eye discharge, and dryness decreased with tap water (P?=?0.020), Eye Shampoo (P?=?0.036), and Eye Brush (P?=?0.014), respectively. Sensations of eye discharge increased after 1?month of using both products (P?=?0.042). The wiping efficacy of Eye Brush, Eye Shampoo or both was significantly greater than that of tap water alone (two-sided test, P?=?0.003, 0.003, 0.002), and using both significantly increased efficacy above Eye Shampoo use alone (one-sided test, P?=?0.009). CONCLUSIONS:Wiping lid margins using Eye Brush enhanced the cleansing power of Eye Shampoo. A daily healthcare routine using both products could be a safe and effective option for daily lid hygiene. TRIAL REGISTRATION:UMIN000016905 . Registration date: March 24, 2015; the study was prospectively registered.

SUBMITTER: Tanabe H 

PROVIDER: S-EPMC6360667 | biostudies-other | 2019 Feb

REPOSITORIES: biostudies-other