Ontology highlight
ABSTRACT:
SUBMITTER: Grab J
PROVIDER: S-EPMC6368550 | biostudies-other | 2019 Feb
REPOSITORIES: biostudies-other
Gräb Jessica J Suárez Isabelle I van Gumpel Edeltraud E Winter Sandra S Schreiber Fynn F Esser Anna A Hölscher Christoph C Fritsch Melanie M Herb Marc M Schramm Michael M Wachsmuth Laurens L Pallasch Christian C Pasparakis Manolis M Kashkar Hamid H Rybniker Jan J
Nature communications 20190208 1
Corticosteroids are host-directed drugs with proven beneficial effect on survival of tuberculosis (TB) patients, but their precise mechanisms of action in this disease remain largely unknown. Here we show that corticosteroids such as dexamethasone inhibit necrotic cell death of cells infected with Mycobacterium tuberculosis (Mtb) by facilitating mitogen-activated protein kinase phosphatase 1 (MKP-1)-dependent dephosphorylation of p38 MAPK. Characterization of infected mixed lineage kinase domain ...[more]