Ontology highlight
ABSTRACT:
SUBMITTER: Sun Y
PROVIDER: S-EPMC6369813 | biostudies-other | 2019 Feb
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 20190122 6
Fluorescent theranostics probes at the second near-IR region (NIR-II; 1.0-1.7 µm) are in high demand for precise theranostics that minimize autofluorescence, reduce photon scattering, and improve the penetration depth. Herein, we designed and synthesized an NIR-II theranostic nanoprobe 1 that incorporates a Pt(II) metallacycle 2 and an organic molecular dye 3 into DSPE-mPEG5000 (1,2-distearoyl-sn-glycero-3-phosphoethanolamine-<i>N</i>-[methoxy(polyethylene glycol)-5000]). This design endows 1 wi ...[more]