Dataset Information

Use of item response theory to develop a shortened version of the EORTC QLQ-BR23 scales.

ABSTRACT: It is important that questionnaires are as short as possible while still capturing the scope of problems relevant in an effective and reliable manner, to minimize the response burden. The purpose of our study was to develop a shortened version of the EORTC QLQ-BR23 for using in breast cancer survivors. Our data come from 10794 breast cancer survivors who completed the EORTC QLQ-BR23. Two-thirds of the sample was randomly selected from the original sample for development, and the remaining was used for validation. Item response theory methods were applied to shorten scales. The graded response model of Samejima was used to fit the item responses. The shortened scale was evaluated with the validation set by examining the mean difference, the proportion of respondents correctly predicted, correlation and weighted kappa between the shortened form and the original observed scores. Results reveal that a three-item BRBI, a four-item BRST, a three-item BRBS and a two-item BRAS forecast the scores on the original scales with wonderful consistency and are alike in measurement precision with no loss or only little loss in detecting group differences. Prospective validation on new diagnosed breast cancer patients and with poor QOL is needed.

SUBMITTER: Xia J

PROVIDER: S-EPMC6370820 | biostudies-other | 2019 Feb

REPOSITORIES: biostudies-other

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Use of item response theory to develop a shortened version of the EORTC QLQ-BR23 scales.

Xia Juan J Tang Zheng Z Wu Peng P Wang Jiwei J Yu Jinming J

Scientific reports 20190211 1

It is important that questionnaires are as short as possible while still capturing the scope of problems relevant in an effective and reliable manner, to minimize the response burden. The purpose of our study was to develop a shortened version of the EORTC QLQ-BR23 for using in breast cancer survivors. Our data come from 10794 breast cancer survivors who completed the EORTC QLQ-BR23. Two-thirds of the sample was randomly selected from the original sample for development, and the remaining was us ...[more]

PMID: 30741988

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Project description:BACKGROUND: Nonparametric item response theory (IRT) was used to examine (a) the performance of the 30 Positive and Negative Syndrome Scale (PANSS) items and their options ((levels of severity), (b) the effectiveness of various subscales to discriminate among differences in symptom severity, and (c) the development of an abbreviated PANSS (Mini-PANSS) based on IRT and a method to link scores to the original PANSS. METHODS: Baseline PANSS scores from 7,187 patients with Schizophrenia or Schizoaffective disorder who were enrolled between 1995 and 2005 in psychopharmacology trials were obtained. Option characteristic curves (OCCs) and Item Characteristic Curves (ICCs) were constructed to examine the probability of rating each of seven options within each of 30 PANSS items as a function of subscale severity, and summed-score linking was applied to items selected for the Mini-PANSS. RESULTS: The majority of items forming the Positive and Negative subscales (i.e. 19 items) performed very well and discriminate better along symptom severity compared to the General Psychopathology subscale. Six of the seven Positive Symptom items, six of the seven Negative Symptom items, and seven out of the 16 General Psychopathology items were retained for inclusion in the Mini-PANSS. Summed score linking and linear interpolation was able to produce a translation table for comparing total subscale scores of the Mini-PANSS to total subscale scores on the original PANSS. Results show scores on the subscales of the Mini-PANSS can be linked to scores on the original PANSS subscales, with very little bias. CONCLUSIONS: The study demonstrated the utility of non-parametric IRT in examining the item properties of the PANSS and to allow selection of items for an abbreviated PANSS scale. The comparisons between the 30-item PANSS and the Mini-PANSS revealed that the shorter version is comparable to the 30-item PANSS, but when applying IRT, the Mini-PANSS is also a good indicator of illness severity.

Project description:PURPOSE:The association of chronic lymphocytic leukemia (CLL) with health-related quality of life (HRQoL) is rarely studied globally. This study evaluated the psychometric properties of the EORTC-Chronic Lymphocytic Leukaemia (CLL17 [phase III]) module, a newly developed assessment on CLL patients' HRQoL, among Chinese CLL patients. METHODS:The Chinese CLL17, comprised of three subscales (symptom burden [SB], physical condition [PC] and worries/fears [WF]), was provided by the developer team through EORTC. A cross-sectional online survey was conducted to collect data. The classical traditional theory (CTT) and the item response theory (IRT) were used to evaluate the psychometric properties of CLL17. Internal consistency reliability was determined by the Cronbach's alpha and item-total correlation. Dimensionality was verified through confirmatory factor analysis (CFA). Convergent validity was also assessed. The generalized partial credit model was used for the IRT. The difficulty, discrimination, item fit, and differential item functioning (DIF) were calculated to assess the instrument's psychometric properties. RESULTS:In all, 318 patients, aged between 26 and 82?years, completed the questionnaire. A good level of internal reliability was achieved (Cronbach's alpha?=?0.92). The item-total correlation coefficient ranged from 0.46 to 0.72. There was a mid-to-high correlation between CLL17 and domains of EQ-5D and QLQ-C30. The IRT model showed a satisfactory homogeneity, item fit and good discrimination of items, except for item 4, 6 and 16 (<?1.0). low information provided by item 16 and 17. SB and PC provided more information with theta >?0, whereas WF provided more information with theta <?0. Item 17 perform inconsistently for respondents from different age groups (DIF). CONCLUSION:The EORTC-CLL17 Chinese version shows acceptable reliability and validity, making it a valuable instrument to evaluate the impact on the HRQoL of Chinese CLL patients.

Dataset Information

Use of item response theory to develop a shortened version of the EORTC QLQ-BR23 scales.

Publications

Use of item response theory to develop a shortened version of the EORTC QLQ-BR23 scales.

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