Ontology highlight
ABSTRACT:
SUBMITTER: Iype J
PROVIDER: S-EPMC6379807 | biostudies-other | 2019 Mar
REPOSITORIES: biostudies-other
Journal of immunology (Baltimore, Md. : 1950) 20190125 5
The random gene segment rearrangement during B cell development ensures Ab repertoire diversity. Because this process might generate autoreactive specificities, it has been proposed that stringent selection mechanisms prevent the development of autoreactive B cells. However, conventional assays to identify autoreactive B cells usually employ in vitro-generated Abs, which differ from membrane-bound BCRs. In this study, we used a cell-based assay to investigate the autoreactivity of membrane-bound ...[more]