Integrated systems approach defines the antiviral pathways conferring protection by the RV144 HIV vaccine.
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ABSTRACT:
SUBMITTER: Fourati S
PROVIDER: S-EPMC6382801 | biostudies-other | 2019 Feb
REPOSITORIES: biostudies-other
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Integrated systems approach defines the antiviral pathways conferring protection by the RV144 HIV vaccine.
Fourati Slim S Ribeiro Susan Pereira SP Blasco Tavares Pereira Lopes Filipa F Talla Aarthi A Lefebvre Francois F Cameron Mark M Kaewkungwal J J Pitisuttithum P P Nitayaphan S S Rerks-Ngarm S S Kim Jerome H JH Thomas Rasmi R Gilbert Peter B PB Tomaras Georgia D GD Koup Richard A RA Michael Nelson L NL McElrath M Juliana MJ Gottardo Raphael R Sékaly Rafick-Pierre RP
Nature communications 20190220 1
The RV144 vaccine trial showed reduced risk of HIV-1 acquisition by 31.2%, although mechanisms that led to protection remain poorly understood. Here we identify transcriptional correlates for reduced HIV-1 acquisition after vaccination. We assess the transcriptomic profile of blood collected from 223 participants and 40 placebo recipients. Pathway-level analysis of HIV-1 negative vaccinees reveals that type I interferons that activate the IRF7 antiviral program and type II interferon-stimulated ...[more]
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