Ontology highlight
ABSTRACT:
SUBMITTER: Gooch KE
PROVIDER: S-EPMC6384896 | biostudies-other | 2019 Feb
REPOSITORIES: biostudies-other
Gooch Karen E KE Marriott Anthony C AC Ryan Kathryn A KA Yeates Paul P Slack Gillian S GS Brown Phillip J PJ Fothergill Ross R Whittaker Catherine J CJ Carroll Miles W MW
Scientific reports 20190222 1
An effective universal vaccine for influenza will likely need to induce virus-specific T-cells, which are the major mediator of heterosubtypic cross-protection between different subtypes of influenza A virus. In this study we characterise the cell-mediated immune response in ferrets during heterosubtypic protection induced by low-dose H1N1 virus infection against an H3N2 virus challenge, given 4 weeks later. Although the ferrets were not protected against the infection by H3N2 virus, the duratio ...[more]