Dataset Information
Pd-catalyzed γ-arylation of γ,δ-unsaturated O-carbamates via an unusual haptotropic rearrangement.
Ontology highlight
ABSTRACT:
SUBMITTER: Royal T
PROVIDER: S-EPMC6385668 | biostudies-other | 2019 Feb
REPOSITORIES: biostudies-other
Publications
Pd-catalyzed γ-arylation of γ,δ-unsaturated <i>O</i>-carbamates <i>via</i> an unusual haptotropic rearrangement.
Chemical science 20181226 8
An unusual <i>γ</i>-selectivity was observed in the arylation of γ,δ-unsaturated <i>O</i>-carbamates involving directed lithiation, transmetallation to zinc and Negishi coupling, when a specific combination of aryl electrophile and phosphine ligand is employed. Mechanistic studies indicate that an unusual, stereospecific haptotropic rearrangement of the palladium-diene intermediate is involved. ...[more]