Ontology highlight
ABSTRACT:
SUBMITTER: Kamalov M
PROVIDER: S-EPMC6390181 | biostudies-other | 2019 Feb
REPOSITORIES: biostudies-other
Kamalov Meder M Kählig Hanspeter H Rentenberger Christian C Müllner Alexander R M ARM Peterlik Herwig H Becker Christian F W CFW
Scientific reports 20190225 1
Here we show that the well-known ovalbumin epitope SIINFEKL that is routinely used to stimulate ovalbumin-specific T cells and to test new vaccine adjuvants can form a stable hydrogel. We investigate properties of this hydrogel by a range of spectroscopic and imaging techniques demonstrating that the hydrogel is stabilized by self-assembly of the peptide into nanofibres via stacking of β-sheets. As peptide hydrogels are known to stimulate an immune response as adjuvants, the immunoactive propert ...[more]