Neutrophil Subsets, Platelets, and Vascular Disease in Psoriasis.

ABSTRACT: Psoriasis is an inflammatory skin disease associated with increased cardiovascular risk and serves as a reliable model to study inflammatory atherogenesis. Because neutrophils are implicated in atherosclerosis development, this study reports that the interaction among low-density granulocytes, a subset of neutrophils, and platelets is associated with a noncalcified coronary plaque burden assessed by coronary computed tomography angiography. Because early atherosclerotic noncalcified burden can lead to fatal myocardial infarction, the low-density granulocyte-platelet interaction may play a crucial target for clinical intervention.

SUBMITTER: Teague HL 

PROVIDER: S-EPMC6390681 | biostudies-other | 2019 Feb

REPOSITORIES: biostudies-other