Ontology highlight
ABSTRACT:
SUBMITTER: Cheng FHC
PROVIDER: S-EPMC6398890 | biostudies-other | 2019 Mar
REPOSITORIES: biostudies-other
Cheng Frank H C FHC Lin Hon-Yi HY Hwang Tzy-Wei TW Chen Yin-Chen YC Huang Rui-Lan RL Chang Chia-Bin CB Yang Weiqin W Lin Ru-Inn RI Lin Ching-Wen CW Chen Gary C W GCW Mai Shu-Yuan SY Lin Jora M J JMJ Chuang Yu-Ming YM Chou Jian-Liang JL Kuo Li-Wei LW Li Chin C Cheng Alfred S L ASL Lai Hung-Cheng HC Wu Shu-Fen SF Tsai Je-Chiang JC Chan Michael W Y MWY Chan Michael W Y MWY
Cancer science 20190125 3
Ovarian cancer is the most lethal cancer of the female reproductive system. In that regard, several epidemiological studies suggest that long-term exposure to estrogen could increase ovarian cancer risk, although its precise role remains controversial. To decipher a mechanism for this, we previously generated a mathematical model of how estrogen-mediated upregulation of the transcription factor, E2F6, upregulates the ovarian cancer stem/initiating cell marker, c-Kit, by epigenetic silencing the ...[more]