Ontology highlight
ABSTRACT:
SUBMITTER: Domise M
PROVIDER: S-EPMC6399353 | biostudies-other | 2019 Mar
REPOSITORIES: biostudies-other
Domise Manon M Sauvé Florent F Didier Sébastien S Caillerez Raphaëlle R Bégard Séverine S Carrier Sébastien S Colin Morvane M Marinangeli Claudia C Buée Luc L Vingtdeux Valérie V
Cell death & disease 20190304 3
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by synaptic loss that leads to the development of cognitive deficits. Synapses are neuronal structures that play a crucial role in memory formation and are known to consume most of the energy used in the brain. Interestingly, AMP-activated protein kinase (AMPK), the main intracellular energy sensor, is hyper-activated in degenerating neurons in several neurodegenerative diseases, including AD. In this context, we asked whethe ...[more]