Ontology highlight
ABSTRACT:
SUBMITTER: Green LA
PROVIDER: S-EPMC6402705 | biostudies-other | 2019 Feb
REPOSITORIES: biostudies-other
Green Lauren A LA Nebiolo Julia C JC Smith Cody J CJ
PLoS biology 20190222 2
Microglia are central nervous system (CNS)-resident cells. Their ability to migrate outside of the CNS, however, is not understood. Using time-lapse imaging in an obstetrical brachial plexus injury (OBPI) model, we show that microglia squeeze through the spinal boundary and emigrate to peripheral spinal roots. Although both macrophages and microglia respond, microglia are the debris-clearing cell. Once outside the CNS, microglia re-enter the spinal cord in an altered state. These peripheral nerv ...[more]