Ontology highlight
ABSTRACT:
SUBMITTER: Mendez-Lopez I
PROVIDER: S-EPMC6413092 | biostudies-other | 2019 Feb
REPOSITORIES: biostudies-other
Méndez-López Iván I Blanco-Luquin Idoia I Sánchez-Ruiz de Gordoa Javier J Urdánoz-Casado Amaya A Roldán Miren M Acha Blanca B Echavarri Carmen C Zelaya Victoria V Jericó Ivonne I Mendioroz Maite M
International journal of molecular sciences 20190218 4
Lamins are fibrillary proteins that are crucial in maintaining nuclear shape and function. Recently, B-type lamin dysfunction has been linked to tauopathies. However, the role of A-type lamin in neurodegeneration is still obscure. Here, we examined A-type and B-type lamin expression levels by RT-qPCR in Alzheimer's disease (AD) patients and controls in the hippocampus, the core of tau pathology in the brain. <i>LMNA</i>, <i>LMNB1,</i> and <i>LMNB2</i> genes showed moderate mRNA levels in the hum ...[more]